No sleep means no new brain cells


Written on Sunday, February 11, 2007 by Gemini


Missing out on sleep may cause the brain to stop producing new cells, a study has suggested. The work on rats, by a team from Princeton University found a lack of sleep affected the hippocampus, a brain region involved in forming memories. The research in Proceedings of the National Academy of Science showed a stress hormone causes the effect. A UK expert said it would be interesting to see if too little rather than no sleep had the same consequence.

The researchers compared ani
mals who were deprived of sleep for 72 hours with others who were not. They found those who missed out on rest had higher levels of the stress hormone corticosterone. They also produced significantly fewer new brain cells in a particular region of the hippocampus.

When the animals’ corticosterone levels were kept at a constant level, the reduction in cell proliferation was abolished. The results suggest that elevated stress hormone levels resulting from sleep deprivation could explain the re
duction in cell production in the adult brain. Sleep patterns were restored to normal within a week.

However, levels of nerve cell production (neurogenesis) were not restored for two weeks, and the brain appears to boost its efforts in order to counteract the shortage. The researchers led said though the role of nerve cell production in adults remained unknown, “the suppression of adult neurogenesis may underlie some of the cognitive deficits associated with prolonged sleep deprivation.”

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