Eye implant that could save the sight of millions...


Written on Wednesday, September 12, 2007 by Gemini

Sensors can monitor production processes, unmask tiny cracks in aircraft hulls, and determine the amount of laundry in a washing machine. In the very near future, they will also be used in the human body to detect and raise the alarm in the event of high pressure in the eye, bladder or brain.


If the pressure in the eye is too high, nerve fibres die, resulting in visual field loss or blindness. Since increased pressure occurring within the eyeball (intraocular pressure), also known as glaucoma, is not usually painful, the condition is often diagnosed too late. Moreover, such patients often tend to develop cataracts when they get older – the lenses of their eyes become opaque.


In such cases, surgeons remove the natural lens and replace it with an artificial one.


To avoid further loss of nerve fibres, the intraocular pressure is then regulated as accurately as possible with the help of medication. Unfortunately, the pressure continues to vary despite medication, obligating the patient to have it constantly monitored by physicians, and the medication dosage adjusted accordingly.


In the future, however, a sensor developed by Germany-based researchers at the Fraunhofer Institute for Microelectric Circuits and Systems IMS will eliminate the need for constant visits to the physician by such patients. “We integrate the 2.5 by 2.6 millimetre sensor in the artificial lens,” says Thomas van den Boom, group manager for biohybrid systems at the IMS. “This doesn’t impair the patient’s vision.”


The top and bottom of the sensor are formed by electrodes; the top electrode is flexible, in contrast to its rigid counterpart on the bottom of the sensor. When the intraocular pressure increases, the top electrode is pushed in, reducing the distance between the top and bottom of the sensor. Using a tiny antenna, the implant sends the pressure data collected from the electrodes to a reader that is fitted into the frame of a pair of spectacles.


The patient can view the results on a handheld device and determine whether the pressure has reached a critical level. An antenna in the spectacle frame supplies the sensor with the required energy via an electromagnetic field, keeping the sensor’s power consumption to an absolute minimum. The permanent eye implant is currently undergoing clinical trials and could come into general use in two to three years’ time.


But the sensor is not only suitable for use in the eye: When implanted in blood vessels in the thigh or the upper arm it can also help patients with chronic hypertension.  “Conventional devices for measuring blood pressure at home are not suitable for determining the correct medication dosage,” says van den Boom. The sensor is also expected to benefit patients suffering from increased intracranial pressure or those with incontinence problems.

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